BSc, PhD
Position: 
NHMRC Senior Research Fellow and Professor of Molecular Virology
Room: 
555
Phone: 
33467219
Role: 
  • Group Leader, RNA Virology Laboratory
  • Chair, External Grants and Fellowships sub-committe, SCMB Reseach Committee 
  • Deputy Director, Australian Infectious Diseases Research Centre
Biography: 

Alexander Khromykh received his BSc degree in Physiology from the Tomsk State University, Russia, and his PhD degree in Molecular Virology from the State Centre for Virology and Biotechnology "Vector”,  Russia. He worked as Postdoctoral Fellow at the University of Ottawa in Canada. He then joined Sir Albert Sakzewski Virus Research Centre in Brisbane in 1992 and became a laboratory Head in 2001.  He was awarded NH&MRC Senior Research Fellowship in 2004 and moved his laboratory to St Luica campus in 2005 to take an appointment with SCMB.  He was the founding Director of the SCMB’s Centre for Infectious Disease Research and is currently the Deputy Director of the Australian Infectious Diseases Research Centre, an NH&MRC Senior Research Fellow and Professor of Virology at SCMB.

Research Focus and Collaborations: 

The main areas of research of the group are molecular virology, viral pathogenesis, and virus-host interactions. The viruses studied in the group are encephalitic flaviviruses, primarily West Nile virus. The goal of the research is to determine the mechanisms by which these viruses cause disease in the hosts and to identify viral and host factors determining the outcome of infection. The group uses a range of classical and more modern approaches including molecular manipulations with viral infectious cDNA clones and replicons, transient and stable expression of viral proteins and noncoding RNAs, viral replication and virulence assays, microarrays, mass spectrometry, next generation sequencing analysis, siRNA knockdowns, and knockout cells and mice. Together, these approaches allow the group to perform detailed analysis of the effects of changes in the viral and host genomes that are likely to have a profound impact on virus replication and pathogenesis.

Research Projects:

  • Molecular pathogenesis of West Nile and Chikungunya viruses
  • Viral evasion of host innate immune response
  • Viral and host small regulatory RNAs
  • Flavivirus non-coding subgenomic RNA
  • Pseudo-infectious flavivirus DNA vaccines
  • Replicon-based vaccine and cancer therapy vectors


Key Collaborators

  • Roy Hall; Paul Young; Mario Lobigs; Helle Bielefeldt-Ohmann; Sassan Asgari; Mark Kendall, University of Queensland
  • Andreas Suhrbier, Queensland Institute of Medical Research
  • Peter Kirkland, Department of Primary Industries, New South Wales
  • Michael Diamond, Washington University School of Medicine, USA
  • David Barton, University of Colorado, USA
  • Yutaro Kumagai; Osamu Takeuchi; Shizuo Akira, Osaka University, Japan
  • Sonia Best, National Institutes of Health, USA
  • Viktor Volchkov, INSERM, France
  • Philippe Despres, Pasteur Institute, France
  • Jeffrey Wilusz; Richard Bowen, Colorado State University, USA
  • Aaron Brault, CDC, USA
  • Gorben Pijlman, Wageningen University, The Netherlands
Funded Projects: 

Khromykh A.A. (2014-2018).  NHMRC Senior Research Fellowship.

Khromykh A.A. (2013-2015). The role of noncoding subgenomic flavivirus RNA in virus-host interactions. NHMRC Project Grant. $602,877

Khromykh, A.A., Hall, R., Bielefeldt-Ohmann, H., Lobigs, M. (2013-2015) Molecular pathogenesis of emerging West Nile viruses. NHMRC Project Grant. $573,627.

Hall, R.A., Khromykh, A.A., van den Hurk, A. (2012-2014). Do insect-specific flaviviruses regulate the transmission of mosquito-borne diseases in Australia? ARC Discovery. $405,000.

Khromykh, A.A., Asgari, S. (2012-2014). Role of flavivirus-encoded small regulatory RNAs in virus-mosquito vector interactions. NHMRC Project Grant. $528,675.

Hall, R.A., Khromykh, A.A., Van-den-Hurk, A., Bielefeldt-Ohmann, H., Kirkland, P. (2012-2014) Emergence of a virulent strain of West Nile virus causing fatal equine encephalitis in South Eastern Australia. ARC Linkage, $390,000

 

Significant Professional Activities and Awards: 

Professional activities:

Treasurer, Australasian Virology Society

Member of Editorial Boards for:  Journal of Virology,  Journal of General Virology, and Open Vaccine Journal

Awards:

2014 NHMRC Senior Research Fellowship

2009 NHMRC Senior Research Fellowship

2008  Long term Invitation Fellowship, Japanese Society for Promotion of Science/ Australian Science     Academy

2004  NHMRC Senior Research Fellowship

Alexander Khromykh in the News

Professor Khromykh and his work were featured in Research Media, Europe's leading Portal for Scientific Dissemination. Read the article.

 

Selected Publications: