Alexander Khromykh received his BSc degree from the Tomsk State University, Russia, and his PhD degree in Molecular Virology from the State Centre for Virology and Biotechnology, NPO Vector”, Russia. He worked as Postdoctoral Fellow at the University of Ottawa in Canada. He then joined Sir Albert Sakzewski Virus Research Centre in Brisbane in 1992 and became a laboratory Head in 2001. He was awarded NH&MRC Senior Research Fellowship in 2004 and moved his laboratory to St Luica campus in 2005 to take an appointment with SCMB. In 2009 he successfully renewed his NHMRC Senior Research Fellowship and was promoted to Professor. He was the founding Director of the SCMB’s Centre for Infectious Disease Research and is currently the Deputy Director of the Australian Infectious Diseases Research Centre.
The main areas of research of the group are molecular virology, viral pathogenesis, and virus-host interactions. The viruses studied in the group are encephalitic flaviviruses, primarily West Nile virus, and alphavirus Chikungunya. The goal of the research is to determine the mechanisms by which these viruses cause disease in the hosts and to identify viral and host factors determining the outcome of infection. The group uses a range of classical and more modern approaches including molecular manipulations with viral infectious cDNA clones and replicons, transient and stable expression of viral proteins and noncoding RNAs, viral replication and virulence assays, microarrays, mass spectrometry, next generation sequencing analysis, siRNA knockdowns, and knockout cells and mice. Together, these approaches allow the group to perform detailed analysis of the effects of changes in the viral and host genomes that are likely to have a profound impact on virus replication and pathogenesis.
Khromykh A.A. (2009-2014). NHMRC Senior Research Fellowship.
Khromykh A.A. (2013-2015). The role of noncoding subgenomic flavivirus RNA in virus-host interactions. NHMRC Project Grant. $602,877
Khromykh, A.A., Hall, R., Bielefeldt-Ohmann, H., Lobigs, M. (2013-2015) Molecular pathogenesis of emerging West Nile viruses. NHMRC Project Grant. $573,627.
Hall, R.A., Khromykh, A.A., van den Hurk, A. (2012-2014). Do insect-specific flaviviruses regulate the transmission of mosquito-borne diseases in Australia? ARC Discovery. $405,000.
Khromykh, A.A., Asgari, S. (2012-2014). Role of flavivirus-encoded small regulatory RNAs in virus-mosquito vector interactions. NHMRC Project Grant. $528,675.
Hall, R.A., Khromykh, A.A., Van-den-Hurk, A., Bielefeldt-Ohmann, H., Kirkland, P. (2012-2014) Emergence of a virulent strain of West Nile virus causing fatal equine encephalitis in South Eastern Australia. ARC Linkage, $390,000
Asgari, S., Khromykh, A.A. (2011-2013). Regulatory cellular microRNAs and their role in insect anti-viral responses. ARC Discovery. $340,000.
Khromykh, A.A., Hall, R.A., Funk, A., Melian, E.B. (2011-2013). Viral factors contributing to flavivirus-induced cell death and pathogenesis. NHMRC Project Grant. $591,732.
Khromykh A.A., Funk, A. (2010-2012). The role of subgenomic non-coding viral RNA in flavivirus pathogenicity. NHMRC Project Grant. $535,500
Hall, R.A, Khromykh A.A., Fairlie, D. A functional interaction between domains of the flavivirus NS5 protein presents a new target for antiviral therapy. NHMRC Project Grant. $485,125.
Treasurer, Australasian Virology Society
Member of Editorial Boards for: Journal of Virology, Journal of General Virology, and Open Vaccine Journal
2009 NHMRC Senior Research Fellowship
2008 Long term Invitation Fellowship, Japanese Society for Promotion of Science/ Australian Science Academy
2004 NHMRC Senior Research Fellowship
Professor Khromykh and his work were featured in Research Media, Europe's leading Portal for Scientific Dissemination. Read the article.