BSc (Ljubljana) Chemistry, PhD (Texas) Biochemistry/Biophysics
Position: 
NHMRC Research Fellow and Professor of Structural Biology
Room: 
329
Phone: 
+61 7 336 52132
Role: 

Group Leader, Protein Structure and Function

Deputy Chair, School of Chemistry and Molecular Biosciences Research Committee

Biography: 

Bostjan Kobe received his BSc (Hons) degree from the University of Ljubljana, Slovenia, and his PhD degree from the University of Texas Soutwestern Medical Center at Dallas, USA, under the supervision of Johann Deisenhofer. He worked as Postdoctoral Fellow at Howard Hughes Medical Institute in Dallas Texas, and at St Vincent's Institute of Medical Research in Melbourne, Australia. He has been at the University of Queensland since the year 2000. He has been awarded the Minister's Prize for Achievement in Life Sciences in 2001, and the ASBMB Roche Medal in 2009. He was awarded the ARC Federation Fellowship in 2005.

Brief Research Description: 
Structural biology of infection and immunity
Research Focus and Collaborations: 

Protein Structure and Function

The group’s research theme is protein structure and function, with the emphasis on understanding the structural basis of intra- and intermolecular interactions formed by these macromolecules and inferring function from structure. The biological focus is on proteins involved in infection and immunity. The goal of the research is to use structural and molecular information to understand the molecular and cellular functions of proteins, validate proteins as therapeutic targets or biotechnological products, and to design new therapeutics and biotechnological applications. The primary technique used in the laboratory is X-ray crystallography, combined with a plethora of other molecular biology, biophysical and computational techniques.

Research Projects

  • Molecular and structural basis of bacterial pathogenesis
  • Molecular and structural basis of innate immunity in animals and plants
  • Molecular and structural basis of nucleo-cytoplasmic transport
  • Molecular and structural basis of viral membrane fusion
  • Development of bioinformatic tools for protein-protein interaction analysis
Funded Projects: 

ARC Discovery Project 2012-2015
Understanding the molecular function of plant disease resistance proteins, pathogen effectors and their interaction to protect Australian agriculture
Total value of grant: $370, 000

NHMRC Senior Research Fellowship 2011-2015
Structural biology of infection and immunity
Total value of grant: $630,505

NHMRC Program 2010-2014
Pathogenesis, treatment and prevention of bacterial infectious diseases
Total value of grant: $1,895,000

ARC Discovery Project 2012-2014
Understanding the molecular function of plant disease resistance proteins, pathogen effectors and their interaction to protect Australian agriculture
Total value of grant:$370,000

NHMRC Project 2011-2013
Molecular and structural basis of signalling by TIR domain-containing adaptors in TLR pathways
Total value of grant:$643,616

NHMRC Development Grant 2010-2012
Developing a safe group A streptococcal vaccine
Total value of grant: $483,600

ARC Federation Fellowship 2005-2010
New Approaches to Functional and Structural Genomics
Total value of grant: $1,551,626

Teaching: 

Advanced Biochemistry and Molecular Biology (BIOC3000)

Cell Structure & Function (BIOL2200)

Foundations of Biophysics (BIPH2000)

Significant Professional Activities and Awards: 

Selected Professional Activities:

Society of Crystallographers in Australia and New Zealand: President 2012-2014

Academic Editor, PLoS One

ARC College of Experts (2012-2015)

Selected Awards:

2014  School of Chemistry and Molecular Biosciences High Impact Research Achievement Award
2011  Q-Index Award for Postgraduate Supervision
2011  NHMRC Senior Research Fellowship
2009  Roche Medal
2005  ARC Federation Fellowship
2003  NHMRC Senior Research Fellowship
2001  Minister's Prize for Achievement in Life Sciences 
2000  Erice Vaciago Award, International School of Crystallography
1998  National Association of Research Fellows of NHMRC Post-Doctoral Award
1997  Wellcome Senior Research Fellowship in Medical Science
1996  ARC Postoctoral Fellowship
1994  University of Texas Southwestern Nominata Award

Highlighted Publication:

You can read the Science article “Structural Basis for Assembly and Function of a Heterodimeric Plant Immune Receptor" here.

Selected Publications: