The Structural Biology and Biochemistry theme at SCMB focuses on understanding basic processes involved in cell regulation and disease at a molecular level.
Biophysical techniques such as x-ray crystallography and nuclear magnetic resonance spectroscopy are being used, together with computer simulations and modelling techniques, to understand at an atomic level how proteins and peptides interact with themselves and other cellular components such as lipids and sugars to form functional complexes.
Biochemical and molecular biology approaches are being used to probe differences in protein expression, interactions or activity associated with different disease states.
Theme Leader: Professor Elizabeth Gillam
|Bioinformatics (analysis, modelling and integration of biological data)|
|Molecular genetics of gene expression and development|
|Biological and synthetic chemistry|
|Organic Chemistry - Glycoscience, drug discovery and biotechnology|
|Sex virulence and evolution in pathogenic fungi|
|Microbial physiology and biochemistry of metalloenzymes|
|Signalling molecules in macrophages and tumour cells|
|Synthesis, methodology, and medicinal chemistry|
|Physical Chemistry - Structure, function, mechanism and pharmaceutical potential of metalloenzymes|
|Cellular response to foreign nucleic acids|
|Organic Chemistry - Synthesis and isolation of complex natural products, method development, medicinal and physical organic chemistry|
|Mechanisms of drug-induced liver damage|