The Structural Biology and Biochemistry theme at SCMB focuses on understanding basic processes involved in cell regulation and disease at a molecular level.

Biophysical techniques such as x-ray crystallography and nuclear magnetic resonance spectroscopy are being used, together with computer simulations and modelling techniques, to understand at an atomic level how proteins and peptides interact with themselves and other cellular components such as lipids and sugars to form functional complexes.

Biochemical and molecular biology approaches are being used to probe differences in protein expression, interactions or activity associated with different disease states.

Theme Leader:  Professor Elizabeth Gillam

Discipline/Theme members

Molecular mechanisms of neurological disease
Biocatalysis and Molecular Toxicology
Protein structure and drug discovery
Structural biology of infection and immunity
Structure and function of molecular machines
Physical and Computational Chemistry - Simulation of biomolecular systems
Metabolism and Microbiome in Pregnancy
Molecular systems glycobiology
Mechanisms of drug-induced liver damage

Other members of the school with research interests in this area

Bioinformatics (analysis, modelling and integration of biological data)
Molecular genetics of gene expression and development
Biological and synthetic chemistry
Organic Chemistry - Glycoscience, drug discovery and biotechnology
Sex virulence and evolution in pathogenic fungi
Microbial physiology and biochemistry of metalloenzymes
Signalling molecules in macrophages and tumour cells
Synthesis, methodology, and medicinal chemistry
Clinical protozoology
Drug discovery (Inflammation, cancer, pathogenic fungi), medicinal chemistry
Bacterial Pathogenesis
Physical Chemistry - Structure, function, mechanism and pharmaceutical potential of metalloenzymes
Cellular response to foreign nucleic acids
Tuberculosis microbiology
Engineering phages to control bacteria biofilms
Organic Chemistry - Synthesis and isolation of complex natural products, method development, medicinal and physical organic chemistry
Mechanisms of drug-induced liver damage
Molecular virology

Affiliated Members

Glenn King

Jenny Martin