BSc Honours (UTS) Biochemistry; PhD (UQ) Molecular Cell Biology
Position: 
National Breast Cancer Foundation Early Career Researcher Fellow
Room: 
430
Phone: 
+ 61 7 336 54634
Biography: 

I completed my PhD in the field of Molecular Cell Biology at The University of Queensland in 2003. I secured a National Health and Medical Research Council CJ Martin Overseas Fellowship that funded a postdoctoral position within the laboratory of Prof. Keith Mostov at the University of California, San Francisco. In 2010 I returned to The University of Queensland's School of Chemistry & Molecular Biosciences. I was awarded a prestigious National Breast Cancer Foundation Fellowship (in 2012) aimed at understanding the role of cellular polarity determinants in breast development and their contribution to breast cancer progression.

Research Focus and Collaborations: 

Understanding the mechanistic basis of epithelial morphogenesis is a major challenge in modern biology, with clear ramifications for human health and disease. The formation of a tissue requires timely and well-orchestrated interactions of cells within their microenvironment. These cellular interactions underpin developmental processes and support normal tissue form and function.  Crucial to normal epithelial tissue function is the establishment of cellular polarity. Epithelial tumours can arise as a result of loss of cellular polarity and it is becoming increasing apparent that the interaction of transformed cells with their microenvironment is instrumental in tumour growth and metastasis. Developing a comprehensive understanding of the basic cell and molecular mechanisms by which polarity proteins control epithelial tissue organisation will provide insight into developmental processes and how these processes are disrupted in diseases of altered polarity.

Annette's research program is focused on understanding how the  polarity machinery of epithelial cells contributes to tissue organisation, and how loss of control of polarity contributes to early events in cellular transformation and tumour progression.

Research projects are available in the following areas:

Molecular mechanisms of cellular transformation.

Polarity protein control of plasma membrane asymmetry: establishing the fence.

Polarised protein trafficking in cell polarity and tissue organisation.

Molecular regulation of tissue growth by polarity protein networks.

Funded Projects: 

National Breast Cancer Foundation Early Career Fellowship: 2012-2016

Role of cellular polarity determinants in breast development and their contribution to breast cancer progression.

Total value of grant: $658,100

 

National Health and Medical Research Council CJ Martin Fellowship: 2006-2012


Role of conserved polarity complex in tubulogenesis

Total value of grant: $363,000

Teaching: 

2012 - ResTeach: BIOL1020 - Cells, Genes and Evolution; and BIOL3006 - Molecular Cell Biology (Practical development)

Significant Professional Activities and Awards: 

2012 National Breast Cancer Foundation Early Career Fellowship

2006 National Health and Medical Research Council CJ Martin Biomedical Fellowship

1999 UQ Graduate School Award - PhD Scholarship

Selected Publications: